Polypeptide Antibiotic Potentiation of Neuromuscular Blocking Agent Postoperatively: A Case Report
During multiple surgical procedures, neuromuscular blocking agents (NMBAs) are administered as part of a general anesthetic to provide muscle relaxation. Examples of commonly administered NMBAs are succinylcholine, rocuronium, vecuronium, and cisatracurium. Administration of other medications during the surgical procedure can cause unexpected interactions, such as affecting the action of the NMBAs. The polypeptide class of antibiotics has been identified as one group of antibiotics that can potentiate NMBAs when administered during the perioperative period. Although the incidence of antibiotic-induced neuromuscular blockade is rare, it is important to be aware of this medication interaction and to know how to manage this potential complication. This report presents one such case with a review of the literature.
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